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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314850
Species: Mus musculus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tjp1decreases expressionISOTjp1 (Rattus norvegicus)6480464CTDNicotine results in decreased expression of TJP1 proteinPMID:20722969
Tjp1decreases expressionISOTJP1 (Homo sapiens)6480464CTDNicotine results in decreased expression of TJP1 proteinPMID:18844224
Tjp1multiple interactionsISOTjp1 (Rattus norvegicus)6480464CTD[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]PMID:20722969
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