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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314850
Species: Mus musculus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tjp1affects localizationISOTJP1 (Homo sapiens)6480464CTDAcetaldehyde affects the localization of TJP1 proteinPMID:17991733 PMID:22563376
Tjp1multiple interactionsISOTJP1 (Homo sapiens)6480464CTDchelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]; PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; Ro 32-0432 inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]PMID:17991733
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