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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314643
Species: Mus musculus
RGD Object: Gene
Symbol: Lhx6
Name: LIM homeobox protein 6
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhx6increases expressionEXP 6480464CTDFolic Acid results in increased expression of LHX6 mRNAPMID:25629700
Lhx6multiple interactionsEXP 6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LHX6 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of LHX6; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LHX6 genePMID:20938992
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