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GENE - TERM ANNOTATION REPORT

RGD ID: 1314217
Species: Mus musculus
RGD Object: Gene
Symbol: Lats2
Name: large tumor suppressor 2
Acc ID: GO:0035329
Term: hippo signaling
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Definition Source(s): PMID:17318211, PMID:18328423, PMID:36347846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lats2involved_inIBAPANTHER:PTN002390470 or UniProtKB:Q9NRM7 or MGI:1354386 or UniProtKB:O95835 or FB:FBgn0011739 or MGI:13338832290270GO_Central GO_REF:0000033
Lats2acts_upstream_of_or_withinIGIMGI:103262 or MGI:1927144 or MGI:19290042290270MGI PMID:18369314

PMID:18369314
Lats2involved_inISOUniProtKB:Q9NRM72290270MGI GO_REF:0000119 MGI:4834177
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