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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314116
Species: Mus musculus
RGD Object: Gene
Symbol: Abcg4
Name: ATP binding cassette subfamily G member 4
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg4multiple interactionsISOAbcg4 (Rattus norvegicus)6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]PMID:22129741
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