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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313987
Species: Mus musculus
RGD Object: Gene
Symbol: Xpc
Name: xeroderma pigmentosum, complementation group C
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xpcaffects response to substanceEXP 6480464CTDXPC protein affects the susceptibility to Benzo(a)pyrenePMID:16094661
Xpcdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of XPC mRNAPMID:20504355 PMID:30020114
Xpcincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of XPC mRNAPMID:19428948
Xpcmultiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to XPC promoter]; Folic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of XPC mRNA]PMID:19654925 PMID:30020114
Xpcaffects response to substanceISOXPC (Homo sapiens)6480464CTDXPC polyA tail polymorphism affects the susceptibility to Benzo(a)pyrenePMID:15471894
Xpcdecreases expressionISOXPC (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of XPC mRNA; Benzo(a)pyrene results in decreased expression of XPC proteinPMID:19748547 PMID:30020114
Xpcincreases expressionISOXPC (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of XPC mRNA; Benzo(a)pyrene results in increased expression of XPC proteinPMID:23894430 PMID:27694624 PMID:32234424
Xpcmultiple interactionsISOXPC (Homo sapiens)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in decreased expression of XPC protein; Folic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of XPC mRNA]PMID:19553035 PMID:30020114
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