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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313979
Species: Homo sapiens
RGD Object: Gene
Symbol: TYMP
Name: thymidine phosphorylase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TYMPdecreases degradationEXP 6480464CTDCisplatin results in decreased degradation of TYMP proteinPMID:21444628
TYMPdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of TYMP mRNAPMID:16568373 PMID:27392435
TYMPdecreases response to substanceEXP 6480464CTDTYMP protein results in decreased susceptibility to CisplatinPMID:21444628
TYMPmultiple interactionsEXP 6480464CTD[Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin; [Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein; [TYMP protein co-treated with DPYD protein] affects the susceptibility to Cisplatin; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; TYMP inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; TYMP inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; TYMP protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; TYMP protein inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; U 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMP protein]PMID:12565868 PMID:14727531 PMID:18728667 PMID:21444628 PMID:21493726
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