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GENE - TERM ANNOTATION REPORT

RGD ID: 1313947
Species: Mus musculus
RGD Object: Gene
Symbol: Upf1
Name: UPF1 RNA helicase and ATPase
Acc ID: GO:0000184
Term: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Definition: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Definition Source(s): GOC:krc, GOC:ma, PMID:10025395
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Upf1involved_inIBAPANTHER:PTN000094512 or PomBase:SPAC16C9.06c or ZFIN:ZDB-GENE-040426-2836 or UniProtKB:Q92900 or FB:FBgn0030354 or SGD:S000004685 or WB:WBGene00004880 or TAIR:locus:21710072290270GO_Central GO_REF:0000033
Upf1involved_inISOUniProtKB:Q929002290270MGI GO_REF:0000119 MGI:4834177
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