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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313517
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF6
Name: activating transcription factor 6
Acc ID: CHEBI:28393
Term: beta-D-glucosamine
Definition: A 2-amino-2-deoxy-D-glucopyranose that is D-glucosamine having a beta-configuration at the anomeric position.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF6increases expressionEXP 6480464CTDGlucosamine results in increased expression of ATF6 mRNAPMID:19383982 PMID:20165829 PMID:33812996
ATF6multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; NUS1 protein inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]PMID:20165829 PMID:33812996
ATF6decreases expressionISOAtf6 (Mus musculus)6480464CTDGlucosamine results in decreased expression of ATF6 mRNAPMID:17178593
ATF6increases expressionISOAtf6 (Rattus norvegicus)6480464CTDGlucosamine results in increased expression of ATF6 mRNAPMID:20165829
ATF6increases expressionISOAtf6 (Mus musculus)6480464CTDGlucosamine results in increased expression of ATF6 proteinPMID:30602124
ATF6multiple interactionsISOAtf6 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]PMID:20165829
ATF6multiple interactionsISOAtf6 (Mus musculus)6480464CTDATF6 protein affects the reaction [Glucosamine results in increased expression of OSTN mRNA]PMID:30602124
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