Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313498
Species: Homo sapiens
RGD Object: Gene
Symbol: PPM1D
Name: protein phosphatase, Mg2+/Mn2+ dependent 1D
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPM1Daffects activityEXP 6480464CTDArsenic Trioxide affects the activity of PPM1DPMID:18482988
PPM1Ddecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of PPM1D proteinPMID:21175813
PPM1Dmultiple interactionsEXP 6480464CTDMIR29A protein affects the reaction [Arsenic Trioxide results in decreased expression of PPM1D protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]PMID:18482988 PMID:21175813
PPM1Dincreases expressionISOPpm1d (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of PPM1D mRNAPMID:29095437
PPM1Dmultiple interactionsISOPpm1d (Mus musculus)6480464CTDMetformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA]PMID:29095437
Go Back to source page   Continue to Ontology report