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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313478
Species: Mus musculus
RGD Object: Gene
Symbol: Ltf
Name: lactotransferrin
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ltfmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of LTF mRNA]; fulvestrant inhibits the reaction [Chlordecone results in increased expression of LTF mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of LTF mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA]PMID:10433208 PMID:17640991 PMID:19654927 PMID:9607801
Ltfincreases expressionISOLTF (Homo sapiens)6480464CTDFulvestrant results in increased expression of LTF mRNAPMID:31646340
Ltfmultiple interactionsISOLTF (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of LTF gene; Fulvestrant inhibits the reaction [arsenite results in decreased expression of LTF mRNA]; Fulvestrant inhibits the reaction [Cadmium results in decreased expression of LTF mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of LTF mRNA]PMID:31601247 PMID:31646340
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