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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313478
Species: Mus musculus
RGD Object: Gene
Symbol: Ltf
Name: lactotransferrin
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ltfincreases expressionEXP 6480464CTDGenistein results in increased expression of LTF mRNAPMID:15289156 PMID:22553218
Ltfincreases expressionISOLtf (Rattus norvegicus)6480464CTDGenistein results in increased expression of LTF mRNA; Genistein results in increased expression of LTF proteinPMID:24487097 PMID:29217487
Ltfmultiple interactionsISOLTF (Homo sapiens)6480464CTD[Genistein co-treated with ESR1 protein] results in increased expression of LTF mRNA; [Genistein co-treated with ESR2 protein] results in increased expression of LTF mRNAPMID:21783566
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