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GENE - TERM ANNOTATION REPORT

RGD ID: 1312738
Species: Homo sapiens
RGD Object: Gene
Symbol: SEC63
Name: SEC63 homolog, protein translocation regulator
Acc ID: GO:0006614
Term: SRP-dependent cotranslational protein targeting to membrane
Definition: The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Definition Source(s): ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SEC63involved_inIEAUniProtKB:Q8VHE0 or ensembl:ENSMUSP00000019937150520179Ensembl GO_REF:0000107
SEC63involved_inIBAMGI:2155302 or PANTHER:PTN000636458 or SGD:S000005780 or UniProtKB:Q9UGP8150520179GO_Central GO_REF:0000033
SEC63acts_upstream_of_or_withinIMP 150520179MGI PMID:22375059

PMID:22375059
SEC63involved_inIEAPANTHER:PTHR24075:SF0150520179TreeGrafter GO_REF:0000118
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