GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ezh2 | affects expression | ISO | Ezh2 (Rattus norvegicus) | 6480464 | CTD | Estradiol affects the expression of EZH2 mRNA | PMID:32145629 | Ezh2 | increases acetylation | ISO | EZH2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased acetylation of EZH2 promoter | PMID:25088689 | Ezh2 | increases expression | ISO | EZH2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of EZH2 mRNA; Estradiol results in increased expression of EZH2 protein | PMID:25088689 PMID:32030086 | Ezh2 | increases expression | ISO | Ezh2 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of EZH2 mRNA; Estradiol results in increased expression of EZH2 protein | PMID:25088689 | Ezh2 | increases methylation | ISO | EZH2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased methylation of EZH2 promoter | PMID:25088689 | Ezh2 | multiple interactions | ISO | EZH2 (Homo sapiens) | 6480464 | CTD | Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]; Estradiol promotes the reaction [EP300 protein binds to EZH2 promoter]; Estradiol promotes the reaction [ESR1 protein binds to EZH2 promoter]; Estradiol promotes the reaction [ESR2 protein binds to EZH2 promoter]; Estradiol promotes the reaction [KMT2C protein binds to EZH2 promoter]; Estradiol promotes the reaction [KMT2D protein binds to EZH2 promoter]; KMT2C mutant form inhibits the reaction [Estradiol results in increased expression of EZH2 mRNA]; KMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]]; KMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to EZH2 promoter]]; KMT2D mutant form inhibits the reaction [Estradiol results in increased acetylation of EZH2 promoter]; KMT2D mutant form inhibits the reaction [Estradiol results in increased expression of EZH2 mRNA]; KMT2D mutant form inhibits the reaction [Estradiol results in increased methylation of EZH2 promoter] | PMID:25088689 | Ezh2 | multiple interactions | ISO | Ezh2 (Rattus norvegicus) | 6480464 | CTD | [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 protein; [Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 mRNA; [Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 protein | PMID:25088689 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |