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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312509
Species: Homo sapiens
RGD Object: Gene
Symbol: HDAC2
Name: histone deacetylase 2
Acc ID: CHEBI:49807
Term: lead(2+)
Definition: A lead cation that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDLead affects the expression of HDAC2 mRNA

PMID:28903495
increases expressionISORGD:6199766480464CTDLead results in increased expression of HDAC2 mRNA, Lead results in increased expression of HDAC2 protein

PMID:29301062
multiple interactionsISORGD:6199766480464CTD[HDAC1 protein co-treated with HDAC2 protein] inhibits the reaction [Lead results in decreased expression of NOTCH2 protein], EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 mRNA], EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 protein], Lead promotes the reaction [HDAC1 protein binds to HDAC2 protein]

PMID:29301062
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.