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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311986
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgdr2
Name: prostaglandin D2 receptor 2
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgdr2affects bindingISOPtgdr2 (Mus musculus)6480464CTDsulindac sulfide binds to PTGDR2 proteinPMID:15563582
Ptgdr2multiple interactionsISOPtgdr2 (Mus musculus)6480464CTD[sulindac sulfide binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]PMID:15563582
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