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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311957
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mus81
Name: MUS81 structure-specific endonuclease subunit
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mus81increases sumoylationISOMUS81 (Homo sapiens)6480464CTDArsenic Trioxide results in increased sumoylation of MUS81 proteinPMID:28318385
Mus81multiple interactionsISOMUS81 (Homo sapiens)6480464CTDMUS81 protein mutant form inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein modified form]PMID:28318385
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