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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311629
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dapk1
Name: death associated protein kinase 1
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dapk1increases expressionISODAPK1 (Homo sapiens)6480464CTDEtoposide results in increased expression of DAPK1 protein; Etoposide results in increased expression of DAPK1 protein modified formPMID:30177839
Dapk1multiple interactionsISODAPK1 (Homo sapiens)6480464CTDDAPK1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of ETS1 protein]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein modified form]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein]PMID:30177839
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