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GENE - TERM ANNOTATION REPORT

RGD ID: 1311608
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Taf6
Name: TATA-box binding protein associated factor 6
Acc ID: GO:0051123
Term: RNA polymerase II preinitiation complex assembly
Definition: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.
Definition Source(s): GOC:txnOH, PMID:15020047, PMID:31300188
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Taf6involved_inISOTAF6 (Homo sapiens)1624291RGD PMID:27007846

PMID:27007846
Taf6involved_inIEAUniProtKB:P49848 or ensembl:ENSP000003895751600115EnsemblGO_REF:0000107

GO_REF:0000107
Taf6involved_inIBAPANTHER:PTN000027265 or SGD:S000003080 or UniProtKB:P498481600115GO_CentralGO_REF:0000033

GO_REF:0000033
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