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GENE - TERM ANNOTATION REPORT

RGD ID: 1311315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Frzb
Name: frizzled-related protein
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Frzbacts_upstream_of_or_withinISOFrzb (Mus musculus)1624291RGDMGI:98956 PMID:19961844

PMID:19961844
Frzbinvolved_inISOFRZB (Homo sapiens)1624291RGD PMID:17471511

PMID:17471511
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