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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc47a1
Name: solute carrier family 47 member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc47a1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SLC47A1 mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Slc47a1decreases activityISOSLC47A1 (Homo sapiens)6480464CTDbisphenol A results in decreased activity of SLC47A1 proteinPMID:27989701
Slc47a1decreases expressionISOSlc47a1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SLC47A1 mRNAPMID:32156529
Slc47a1decreases methylationISOSLC47A1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of SLC47A1 genePMID:31601247
Slc47a1multiple interactionsISOSLC47A1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of SLC47A1 gene; bisphenol A inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]PMID:27989701 PMID:31601247
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