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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Acc ID: CHEBI:17552
Term: GDP
Definition: A purine ribonucleoside 5'-diphosphate resulting from the formal condensation of the hydroxy group at the 5' position of guanosine with pyrophosphoric acid.
Chemical ID: MESH:D006153
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sos1multiple interactionsISOSOS1 (Homo sapiens)6480464CTD[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] promotes the reaction [HRAS protein binds to Guanosine Diphosphate]; Enzyme Inhibitors inhibits the reaction [SOS1 protein binds to [HRAS protein binds to Guanosine Diphosphate]]; KRAS protein mutant form inhibits the reaction [SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]]; SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]PMID:25825487 PMID:28154176
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