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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310914
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pip5k1baffects methylationISOPIP5K1B (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PIP5K1B 5' UTR; Benzo(a)pyrene affects the methylation of PIP5K1B intronPMID:27901495 PMID:30157460
Pip5k1bdecreases expressionISOPIP5K1B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PIP5K1B mRNAPMID:20106945 PMID:21632981 PMID:26238291
Pip5k1bincreases methylationISOPIP5K1B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PIP5K1B exon; Benzo(a)pyrene results in increased methylation of PIP5K1B promoterPMID:27901495
Pip5k1bincreases methylationISOPip5k1b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of PIP5K1B intronPMID:27901495
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