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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prss22
Name: serine protease 22
Acc ID: CHEBI:75998
Term: trametinib
Definition: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Chemical ID: MESH:C560077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prss22multiple interactionsISOPRSS22 (Homo sapiens)6480464CTD[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS22 mRNAPMID:36139627
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