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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310687
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Elf3
Name: E74 like ETS transcription factor 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elf3affects methylationISOELF3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ELF3 promoterPMID:27901495
Elf3decreases expressionISOElf3 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ELF3 mRNAPMID:22228805
Elf3decreases methylationISOELF3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ELF3 5' UTRPMID:27901495
Elf3increases expressionISOELF3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ELF3 mRNAPMID:20106945 PMID:21632981 PMID:22316170
Elf3increases expressionISOElf3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ELF3 mRNAPMID:14625279 PMID:22228805
Elf3multiple interactionsISOElf3 (Mus musculus)6480464CTD[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ELF3 mRNA]PMID:14625279
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