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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310639
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccna1
Name: cyclin A1
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccna1decreases expressionISOCCNA1 (Homo sapiens)6480464CTDtrichostatin A results in decreased expression of CCNA1 mRNAPMID:17698632
Ccna1increases expressionISOCCNA1 (Homo sapiens)6480464CTDtrichostatin A results in increased expression of CCNA1 mRNAPMID:24935251
Ccna1multiple interactionsISOCCNA1 (Homo sapiens)6480464CTDtrichostatin A inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; trichostatin A promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; trichostatin A promotes the reaction [H4C16 protein modified form binds to CCNA1 promoter]PMID:17698632
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