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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310590
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eps8
Name: EGFR pathway substrate 8, signaling adaptor
Acc ID: CHEBI:31348
Term: capecitabine
Definition: A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Chemical ID: MESH:C110904
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eps8increases response to substanceISOEPS8 (Homo sapiens)6480464CTDEPS8 protein results in increased susceptibility to CapecitabinePMID:16734730
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