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RGD ID: 1310568
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp2
Name: poly (ADP-ribose) polymerase 2
Acc ID: GO:0005730
Term: nucleolus
Definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
Definition Source(s): ISBN:0198506732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp2located_inISOParp2 (Mus musculus)1624291RGD PMID:15615785

Parp2located_inISOPARP2 (Homo sapiens)1624291RGD PMID:15615785

Parp2located_inISOPARP2 (Homo sapiens) or UniProtKB:Q9UGN5-1 or UniProtKB:Q9UGN5-21624291RGD GO_REF:0000052
Parp2is_active_inIBAFB:FBgn0010247 or MGI:1340806 or MGI:1341112 or PANTHER:PTN002235215 or UniProtKB:P09874 or UniProtKB:Q9UGN51600115GO_CentralGO_REF:0000033

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