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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Acc ID: CHEBI:76612
Term: ibrutinib
Definition: A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies.
Chemical ID: MESH:C551803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k14decreases response to substanceISOMAP3K14 (Homo sapiens)6480464CTDMAP3K14 protein mutant form results in decreased susceptibility to ibrutinibPMID:26254443
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