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GENE - TERM ANNOTATION REPORT

RGD ID: 1310258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f7
Name: E2F transcription factor 7
Acc ID: GO:0003714
Term: transcription corepressor activity
Definition: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
Definition Source(s): GOC:txnOH-2018, PMID:10213677, PMID:16858867
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:13210551624291RGD MGI:MGI:5319718, MGI:MGI:5448509, MGI:MGI:5449497, PMID:22180533, PMID:22516201, PMID:23064266
 ISSUniProtKB:Q6S7F21600115UniProtGO_REF:0000024

GO_REF:0000024
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