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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tmtc2
Name: transmembrane O-mannosyltransferase targeting cadherins 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tmtc2affects methylationISOTMTC2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TMTC2 intronPMID:30157460
Tmtc2decreases expressionISOTmtc2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TMTC2 mRNAPMID:19770486 PMID:21715664
Tmtc2decreases expressionISOTMTC2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TMTC2 mRNAPMID:20106945 PMID:21632981 PMID:22316170
Tmtc2decreases methylationISOTmtc2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of TMTC2 intronPMID:27901495
Tmtc2increases expressionISOTmtc2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of TMTC2 mRNAPMID:22228805
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