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RGD ID: 1309780
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car1
Name: carbonic anhydrase 1
Acc ID: CHEBI:27690
Term: acetazolamide
Definition: A thiadiazole that has formula C4H6N4O3S2.
Chemical ID: MESH:D000086
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13203026480464CTDAcetazolamide results in decreased activity of CA1 protein

PMID:11430635, PMID:19231207, PMID:28117934, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031
multiple interactionsISORGD:13203026480464CTDAcetazolamide binds to and results in decreased activity of CA1 protein, Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein]

PMID:11430635, PMID:17826101, PMID:28251759
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.