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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309681
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npas2
Name: neuronal PAS domain protein 2
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npas2multiple interactionsEXP 6480464CTD(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased splicing of NPAS2 mRNA]PMID:32312805
Npas2affects response to substanceISONpas2 (Mus musculus)6480464CTDNPAS2 affects the susceptibility to CocainePMID:23776671
Npas2decreases expressionISONpas2 (Mus musculus)6480464CTDCocaine results in decreased expression of NPAS2 mRNAPMID:15994025
Npas2increases expressionISONpas2 (Mus musculus)6480464CTDCocaine results in increased expression of NPAS2 mRNAPMID:23776671
Npas2multiple interactionsISONpas2 (Mus musculus)6480464CTDCocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]PMID:23776671
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