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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309606
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nnmt
Name: nicotinamide N-methyltransferase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nnmtdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NNMT mRNAPMID:21215274
Nnmtaffects expressionISONnmt (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NNMT mRNAPMID:21570461
Nnmtdecreases expressionISONnmt (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NNMT mRNAPMID:19770486 PMID:28213091
Nnmtincreases expressionISONnmt (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of NNMT mRNAPMID:17942748
Nnmtmultiple interactionsISONnmt (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NNMT mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of NNMT mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NNMT gene]PMID:17942748 PMID:25975270 PMID:28213091
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