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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Exo1
Name: exonuclease 1
Acc ID: CHEBI:42068
Term: idarubicin
Definition: An anthracycline antibiotic that has formula 497.49392.
Chemical ID: MESH:D015255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13198216480464CTDIdarubicin results in decreased expression of EXO1 mRNA, Idarubicin results in decreased expression of EXO1 protein

PMID:28973540
multiple interactionsISORGD:13198216480464CTDDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA], Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]

PMID:28973540
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