GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Appl1 | multiple interactions | ISO | Appl1 (Mus musculus) | 6480464 | CTD | APPL1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; APPL1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKE protein]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; DNM2 protein promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Lipopolysaccharides inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to IKBKE protein]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to NAP1 protein]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to TANK protein]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to TBK1 protein modified form]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to TBK1 protein]; Lipopolysaccharides promotes the reaction [APPL1 protein binds to TRAF3 protein]; Lipopolysaccharides results in increased ubiquitination of and results in increased degradation of APPL1 protein; N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; U 0126 inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein] | PMID:25780039 | | ||||||||||||||||||||||
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