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GENE - TERM ANNOTATION REPORT

RGD ID: 1309381
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dicer1
Name: dicer 1 ribonuclease III
Acc ID: GO:0070578
Term: RISC-loading complex
Definition: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
Definition Source(s): GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEAUniProtKB:Q9UPY3, ensembl:ENSP000004372561600115EnsemblGO_REF:0000107

GO_REF:0000107
 ISORGD:13196991624291RGD (PMID:15973356), (PMID:16357216), (PMID:17531811), (PMID:18178619), (PMID:19820710), (PMID:23661684)

PMID:15973356, PMID:16357216, PMID:17531811, PMID:18178619, PMID:19820710, PMID:23661684
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.