GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hipk2 | decreases expression | ISO | HIPK2 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in decreased expression of HIPK2 protein | PMID:19714248 | Hipk2 | multiple interactions | ISO | HIPK2 (Homo sapiens) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]; cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]; cobaltous chloride inhibits the reaction [HIPK2 protein binds to HIF1A promoter]; cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of BCL2 mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]]; HIPK2 protein inhibits the reaction [cobaltous chloride results in decreased degradation of and results in increased activity of HIF1A protein]; HIPK2 protein inhibits the reaction [cobaltous chloride results in decreased susceptibility to Doxorubicin]; MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein] | PMID:19128456 PMID:19714248 | |
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