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GENE - TERM ANNOTATION REPORT

RGD ID: 1309279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tk2
Name: thymidine kinase 2
Acc ID: DOID:0070329
Term: mitochondrial DNA depletion syndrome
Definition: A mitochondrial metabolism disease that is characterized by significant reduction in mitochondrial DNA in affected tissues, resulting in impaired mtDNA-encoded protein synthesis and energy production in the affected tissues and organs. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Mitochondrial_DNA_depletion_syndrome "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/28215579 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/29344903 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/29950321 "DO" "DO", https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=35698 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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