Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1309270
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Gli2
Name:	GLI family zinc finger 2

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Gli2	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of GLI2 protein	PMID:31612257
Gli2	multiple interactions	EXP		6480464	CTD	Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]]	PMID:31612257
Gli2	decreases expression	ISO	GLI2 (Homo sapiens)	6480464	CTD	Cisplatin results in decreased expression of GLI2 mRNA	PMID:27392435
Gli2	multiple interactions	ISO	GLI2 (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with jinfukang] results in decreased expression of GLI2 mRNA	PMID:27392435

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