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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309255
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl12
Name: chemokine (C-C motif) ligand 12
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13194986480464CTDBleomycin results in decreased expression of CCL12 mRNA

PMID:29720568
increases expressionISORGD:13194986480464CTDBleomycin results in increased expression of CCL12 mRNA

PMID:28434932
multiple interactionsISORGD:13194986480464CTD[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA], [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA], [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA], [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA], [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA], CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]], Dinoprostone inhibits the reaction [Bleomycin results in increased expression of CCL12 mRNA]

PMID:28434932
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.