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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irx1
Name: iroquois homeobox 1
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irx1increases expressionISOIRX1 (Homo sapiens)6480464CTDbelinostat results in increased expression of IRX1 mRNAPMID:26272509
Irx1multiple interactionsISOIRX1 (Homo sapiens)6480464CTD[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX1 mRNAPMID:27188386
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