GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ncoa1 | multiple interactions | EXP | | 6480464 | CTD | Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]; ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | PMID:19460436 | Ncoa1 | affects localization | ISO | Ncoa1 (Mus musculus) | 6480464 | CTD | Estradiol affects the localization of NCOA1 protein | PMID:17556502 | Ncoa1 | decreases expression | ISO | NCOA1 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of NCOA1 mRNA | PMID:19167446 PMID:19619570 PMID:21185374 | Ncoa1 | increases expression | ISO | NCOA1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of NCOA1 mRNA; Estradiol results in increased expression of NCOA1 protein | PMID:19432593 PMID:27576059 PMID:31646340 | Ncoa1 | multiple interactions | ISO | NCOA1 (Homo sapiens) | 6480464 | CTD | [Estradiol binds to ESR2 protein] which results in increased expression of NCOA1 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCOA1 mRNA; [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Estradiol; [Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to TMEM121B gene]]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to NKD1 gene]]; Estradiol analog promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]; Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]; Estradiol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estradiol promotes the reaction [ESR2 protein binds to NCOA1 protein]; Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]; Estradiol promotes the reaction [NCOA1 protein binds to CTSD promoter]; Estradiol promotes the reaction [NCOA1 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA1 protein binds to ESR2 protein]; Estradiol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]; Estradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA1 protein binds to TFF1 promoter]; Estradiol promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]] | PMID:10964929 PMID:15236964 PMID:15650019 PMID:16489025 PMID:16819505 PMID:17135255 PMID:17872375 PMID:17962382 PMID:19619570 PMID:19838210 PMID:20332105 PMID:20404318 PMID:21768169 PMID:23383871 PMID:23665804 PMID:27156127 PMID:27366082 PMID:29389661 PMID:32088792 | Ncoa1 | multiple interactions | ISO | Ncoa1 (Mus musculus) | 6480464 | CTD | Estradiol promotes the reaction [NR1I3 protein binds to NCOA1 protein]; NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]; NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein] | PMID:23015691 PMID:27634370 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |