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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa1
Name: nuclear receptor coactivator 1
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa1affects methylationEXP 6480464CTDMethoxychlor affects the methylation of NCOA1 genePMID:35440735
Ncoa1multiple interactionsEXP 6480464CTDMethoxychlor metabolite promotes the reaction [ESR1 protein binds to NCOA1 protein]PMID:14613717
Ncoa1multiple interactionsISONCOA1 (Homo sapiens)6480464CTDMethoxychlor promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]PMID:21924250
Ncoa1multiple interactionsISONcoa1 (Mus musculus)6480464CTDMethoxychlor promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]PMID:18973326
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