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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhx30
Name: DExH-box helicase 30
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhx30increases expressionEXP 6480464CTDbisphenol A results in increased expression of DHX30 mRNAPMID:25181051 PMID:34947998
Dhx30increases methylationEXP 6480464CTDbisphenol A results in increased methylation of DHX30 genePMID:28505145
Dhx30decreases expressionISODHX30 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of DHX30 proteinPMID:37567409
Dhx30multiple interactionsISODHX30 (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form]; bisphenol A inhibits the reaction [ESR1 protein binds to DHX30 protein]PMID:28751236 PMID:29389661
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