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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif3c
Name: eukaryotic translation initiation factor 3, subunit C
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif3cdecreases expressionISOEIF3C (Homo sapiens)6480464CTDClodronic Acid results in decreased expression of EIF3C mRNAPMID:25596134
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