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GENE - TERM ANNOTATION REPORT

RGD ID: 1308737
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pias4
Name: protein inhibitor of activated STAT, 4
Acc ID: GO:0003712
Term: transcription coregulator activity
Definition: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
Definition Source(s): GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pias4enablesIBAMGI:2136940 or PANTHER:PTN001324782 or UniProtKB:Q8NF64 or UniProtKB:Q9ULJ61600115GO_CentralGO_REF:0000033

GO_REF:0000033
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