GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases abundance | EXP | | 6480464 | CTD | SIRT1 protein results in decreased abundance of NAD | PMID:19288225 | Sirt1 | increases activity | EXP | | 6480464 | CTD | NAD results in increased activity of SIRT1 protein | PMID:19288225 PMID:22561310 | Sirt1 | increases response to substance | EXP | | 6480464 | CTD | SIRT1 protein results in increased susceptibility to NAD | PMID:22561310 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [SIRT1 protein results in decreased abundance of NAD]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | PMID:19288225 PMID:22561310 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD promotes the reaction [Oleic Acid results in decreased activity of SIRT1 protein]]; [[Resveratrol results in increased activity of and results in increased phosphorylation of SIRT1 protein] which co-treated with NAD] results in decreased acetylation of TP53 protein; [Resveratrol results in increased abundance of NAD] which results in increased expression of SIRT1 protein; NAD promotes the reaction [Oleic Acid results in decreased activity of SIRT1 protein] | PMID:19928762 PMID:25536389 PMID:34216621 | Sirt1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein | PMID:23834033 | | ||||||||||||||||||||||
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