GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases expression | EXP | | 6480464 | CTD | Fructose results in decreased expression of SIRT1 mRNA; Fructose results in decreased expression of SIRT1 protein | PMID:25108154 PMID:26488877 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]; [Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; Fructose results in increased expression of and results in increased activity of SIRT1 protein; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] | PMID:21212096 PMID:25108154 PMID:26488877 PMID:34939712 | Sirt1 | increases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Fructose results in increased expression of SIRT1 protein | PMID:18192211 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | [Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein] | PMID:32730863 | Sirt1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] | PMID:18192211 | | ||||||||||||||||||||||
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