GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of SIRT1 protein | PMID:29966675 PMID:31545955 PMID:37030624 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [Doxorubicin affects the localization of NFE2L2 protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of GPX4 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of GPX4 mRNA]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of HMOX1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of KEAP1 protein] | PMID:29966675 PMID:37030624 | Sirt1 | affects response to substance | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | SIRT1 protein affects the susceptibility to Doxorubicin | PMID:19839049 | Sirt1 | affects response to substance | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | SIRT1 protein affects the susceptibility to Doxorubicin | PMID:37030624 | Sirt1 | decreases activity | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased activity of SIRT1 protein | PMID:25665036 PMID:26450947 | Sirt1 | decreases expression | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of SIRT1 mRNA | PMID:29803840 PMID:36634904 | Sirt1 | decreases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of SIRT1 protein | PMID:36811345 | Sirt1 | decreases response to substance | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | SIRT1 protein results in decreased susceptibility to Doxorubicin | PMID:28456571 | Sirt1 | increases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of SIRT1 protein | PMID:31768571 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein; Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of NRF1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of TFAM protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of VDAC1 protein]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]]; SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]] | PMID:28456571 | Sirt1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; Doxorubicin affects the reaction [SIRT1 protein affects the acetylation of ACSS1 protein]; Doxorubicin affects the reaction [SIRT1 protein affects the acetylation of BMAL1 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of GPX4 protein]; SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of COL1A1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of HMOX1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of MMP9 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of TGFB1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]] | PMID:25665036 PMID:26450947 PMID:31768571 PMID:36811345 PMID:37030624 | | ||||||||||||||||||||||
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